Sperm Donation is a voluntary and noble act through which a healthy male with very high quality semen donates his sperm so that an infertile couple can have a child.
When there is no possibility of retrieving sperms naturally or by a surgical procedure from a male partner, the couple needs donor sperm. The donor sperm is used to either inseminate the woman through IUI or to fertilise her eggs in an IVF / ICSI process and eventually, help the desired mother in conception. The sperm may be donated
The sperm bank is a facility at which human sperm is collected from the donor, stored and used for women who need donor sperm to achieve pregnancy.
Counseling is an important part of this process so that all concerns and questions are addressed and all aspects of this treatment are considered.
Everyone who is a donor must go for certain blood and urine tests to ensure whether he has infections such as Gonorrhoea, Chlamydia, Streptococcal species, Syphilis, Hepatitis B, Cytomegalovirus (CMV) and Trichomonas. All these infections can easily spread via semen to a woman. Some of these infections have a great effect on the fetus; while others affect the woman greatly.
The donor’s semen needs to be checked for the appearance of white blood cells which can symbolise an underlying infection within the reproductive tract.
Before starting DI, a thorough medical and reproductive history needs to be taken on the recipient woman and other tests like blood type, rubella titer, an antibody test for CMV also should be carried out. If the woman’s tests come out negative for CMV, then a CMV-negative donor should only be used for such a procedure.
Prospective donors are first asked to provide a semen sample for testing. All semen samples are produced through masturbation and must be produced on-site in a room specially allocated for semen collection. Suitability is determined by both the sperm count and by their ability to swim (motility).
All samples are frozen in nitrogen at around -190°C and checked once more when they are thawed. Many do not survive this freezing / thawing process and this is the main reason for rejecting prospective donors. Potential donors must be aware that after examination, the majority (almost 90%) of the semen specimens fail to reach the very strict criteria required (although in most cases this does not mean that these men have reduced fertility).
The highest success rates for sperm donation are found in women suffering from no infertility issues and are below 35 years of age and only the male partners have infertility. The success rates become much lower when female factors like ovulation problem, endometriosis, DES etc. are involved or the woman is above the age of 35.Success rates range from 60 - 80% for this procedure but getting pregnant may take many cycles.
Egg (Ovum) Donation is a process where a fertile woman (whose ovary releases an egg at timely intervals) donates her egg to an infertile couple if the desired mother is unable to produce suitable healthy eggs.
The donor egg is fertilised with the sperms from the male partner through IVF or ICSI procedure. Then resulting embryo(s) are transferred to the womb of the desired mother for conception.
If one is looking for participating in the donor program, she will have to apply in writing. The prospective donors need to attend an interview regarding verification of their Age | Health status | History of IVF cycles etc.
Then various examinations will be done to assess her physical and psychological health. Only then a donor is eligible to be matched with a suitable recipient couple. We keep a record of the donor's physical characteristics to help us match her eggs to the recipient couples. Donor’s information is shared with the intending couples which includes her religion, marital status, age and so on.Donor will be screened thoroughly with tests such as
The Egg donors should be in the age group of 21 to 35 years, preferably in the younger side of 20s. A potential donor undergoes Transvaginal ultrasound to see her Antral Follicle Count (AFC). A good AFC count is indicative of good ovarian reserve and a good response to ovarian stimulation.
She will be counselled about the egg donation process, consecutive risk factors or complications and legalities. The donation process will start after her consent.
A series of tests are done and the donor is screened to assess her physical and psychological health.
Our experts will correlate the donor menstrual cycle with the recipient cycle. The donor will self-administer daily injections / medications to suppress her natural menstrual cycle and restart it at the time of the recipient's cycle.
The recipient’s uterine lining or endometrium should be ready for embryo implantation at the time of donor’s egg retrieval and fertilisation. So their menstrual cycles should be on at the same time.
The egg donor uses daily injections of gonadotropin to stimulate her ovaries. In a natural cycle, only one egg matures; gonadotropins injections encourage more than one egg to mature for retrieval.
During ovarian stimulation, the donor will be monitored closely through blood tests and ultrasound, ensuring that the ovaries are responding well and not going into hyperstimulation.
The recipient starts to take estrogen and progesterone medications for preparing her endometrial lining ready for embryo implantation. Developing the endometrium for embryo transfer is usually not a problem.
A favorable uterine environment, especially an endometrium of at least 7 mm, is crucial in the success of embryo implantation.
In rare cases, some patients have difficulties in reaching minimal endometrial thickness and may require special treatments.
When the ultrasound imaging shows that the donor’s eggs have sufficiently developed, she will be administered an injection of hCG to trigger ovulation.
Donor’s eggs are retrieved in a short in-clinic procedure, called egg retrieval. While the donor is under IV sedation, physicians will use an aspiration needle, guided by ultrasound, to retrieve the eggs transvaginally.
The donor may require to take rest for a day or two to recover and get back to normal.
The retrieved eggs will be fertilised with the partner’s (recipient's partner) sperm or a donor’s sperm in the lab and embryos are formed.
If using fresh sperm, her partner will need to visit our clinic to give his semen sample on the retrieval day.
Normally, the best embryo is transferred into her uterus on day 3 after donor egg retrieval or on day 5, in case of blastocyst transfer.
The recipient will have a pregnancy test two weeks after the embryo transfer, via a blood test that measures the level of hCG and an ultrasound will be done.
Using a Donor Egg for IVF is a delicate process with many steps and success rate varies considering various IVF stages and recipient health factors.
65% Overall, the percentage of donor-egg embryo transfers resulting in live birth is consistently above 60-65%.
Whereas, each stage of the process also has its own success rates: the chance of a fertilised donor egg producing properly developing embryos is about 80%, the chance that those embryos will implant correctly in a uterus is about 75-85%,
As a woman ages, her reproductive capabilities slowly taper off. Women over 35 often have trouble conceiving, both naturally and when using their own eggs in IVF. With a donor egg (Egg donors are typically in their 20s), the effects of age are essentially reversed, drastically improving the successful Live Birth Rate (LBR) for women of 40-45.
Donor Egg IVF
Embryo Donation refers to the procedure where healthy anonymous donor eggs are fertilised with anonymous donor sperm and one or two of resultant embryos are placed in the womb of the desired mother at an opportune time so that she can conceive.
Couples having severe infertility issues with both of the sperm and egg factors can opt for the procedure.
Embryo donation (Embryo Adoption) can also be described as adopting a child and giving birth to it.
We maintain a record of all the characteristics of the donor couples to make the best match between the embryos and their recipients.
If the donor embryo is produced from sperm and egg donors, both of them are anonymous, scheduled donor screening rules are followed strictly.
However, it is essential for the couple to understand, grasp and accept the fact that resultant offspring will not be their genetic child but will be their biological child. It is a prerequisite that the couples undergo thorough counselling and are mentally prepared for this form of treatment.
The average pregnancy success rate using embryo donation is 40%. This number is slightly higher than standard IVF implantation success rates.
for patients 35 or younger, there is a 60% pregnancy rate with donor embryos.
women over the age of 40 have a 20% pregnancy rate with donor embryos.
Generally, the donated or adopted embryos have undergone preimplantation genetic testing which results in higher success rates. Another factor that determines the success rate of donor embryo implantation is the age of the woman at the time of egg donation.