As ICSI is an improvisation of conventional IVF cycle and is performed simultaneously, the same precautions should be taken as advised for IVF, like
In case of Pre-implementation Genetic Diagnosis (PGD) with IVF, to genetically screen embryos, sperms that have not fertilised the egg also surround the embryo. This can result in inaccurate results of PGD. ICSI ensures that non-participating sperms do not influence the diagnosis.
Fertilisation rates, embryo quality and pregnancy rates in those who have had ICSI are identical to those in couples who have had IVF without ICSI.
in Intracytoplasmic Sperm Injection
Not all eggs that fertilise end up in developing into healthy embryos. It may be possible for some embryos and eggs to get damaged during the process of ICSI.
Couples using ICSI along with IVF have a 30-35% increased chance of conceiving twins and 5%-10% chances of having triplets. When the mother carries multiples, there are increased risks of certain complications during pregnancy and childbirth, which includes high blood pressure, gestational diabetes, low amniotic fluid levels, premature labor or need of cesarean section.
There is a 1.5%-3% risk of a major birth defect with normal pregnancy. The risk of birth defects is increased slightly with ICSI treatment, although it's rare nonetheless. Some birth defects are associated with ICSI are Angelman Syndrome, Beckwith-Wiedemann Syndrome, sex chromosome abnormalities and hypospadias.
Also, the risk of a male offspring having fertility issues increases slightly. There is a possibility of genetic transfer of infertility.